Clinical Trials and Medical Blog

Some people, it seems, are endowed with a healthy immune system. They never seem to get sick and, if they do get the odd cold, they continue their daily routine and snap out of it in no time flat. Then you see others who barely have to hear the word ‘flu or see someone blowing their nose and bam, they’ve got it!

Is it all in the head? Are you born with a strong immune system to fight off disease? Can you do something about it, if you’re not? Anyway, what does it mean to have immunity? Well, a very simple explanation is that there are basically two types: active and passive immunity.

The definition of ‘immune’ is that your body is so strong and resistant to any disease that you will not succumb to it.

Active immunity is considered to be long-lasting and tends to be life-long. If you’re in this category then, whenever you’re exposed to a disease organism, your immune system will instantly start to produce antibodies to that disease. Furthermore, if you should come into contact with that disease in the future, your immune system will identify it and immediately fight it off with the stored antibodies.

Passive immunity is not inherent in your system. It is when you cannot produce enough antibodies to fight off disease, and get an external boost by injection, medication or nutritional supplements.

Healthy people with an active, innate immunity are usually referred to as being resistant to disease in general. The term immunity is usually applied to general protection against a specific organism. Even if you are generally healthy, you may from time to time need a boost in order to help fight off a virulent strain of a specific infection or virus. The more severe the disease producing organism, the more the passive immunity is applied.

The medical profession recommends boosting your inherent immunity with specific antibodies to fight off a potentially dangerous infection or virus.

A good digestion and healthy appetite are indicators of a strong immunity. “Getting better quickly is a better indicator of immune health,” says Dr Dennis Alexander, head of molecular immunology at the Babraham institute in Cambridge.

Immune globulin can be administered to provide immediate protection from specific health threats to those who have a severely impaired or suppressed immune system. For instance, some who may normally have fairly good resistance to disease suddenly realize that their system cannot handle the sudden onslaught of germs in the hospital.

Likewise, the body under stress, i.e. disease or sudden accident, is often not capable to fight off multiple vaccines in one shot.

Judging by the large numbers of people coping with disease, the human system is inherently fragile and cannot handle multiple onslaughts, like the ones discussed above.

Many believe that if you are generally healthy and look after your health, you will only have a mild version of what’s going around. “In truth, there’s no such thing as a normal immune system,” says Angus Dalgleish, professor of oncology at St George’s Hospital, London, who researches cancer vaccines. He says the system is naturally very variable.

The rise of allergies, auto-immune diseases (where the body attacks itself) and inflammatory bowel disease are all indicators of immune resistance performing under par.

Both types of acquired immunity respond to peptide sequences called antigens. Antigens help the acquired immune system recognize invading bacteria, viruses and other harmful organisms (pathogens).

Leftovers, non-organic foods, and foods laced with preservatives can severely tax the digestive system. This can, in turn, clog your circulation, and create a sluggish, compromised immune system.

Going to be late, working at night, irregular eating habits, sleeping during the day, and exposing the body to stress and fatigue can all affect the digestion and body rhythms and thus compromise your resistance.

Therefore, be good to yourself. Eating nutritiously and keeping an active, happy lifestyle will go a long way to boosting your immune system.

Acid reflux, or gastroesophageal reflux disease (GERD) is a relatively common problem, affecting up to seven million Americans, according to the U.S. Department of Health and Human Services.

But you don’t need to suffer from this uncomfortable backing up of stomach acid that manifests as heartburn, regurgitation of stomach liquid and nausea. And you don’t need to resign yourself to taking a pill every day for the rest of your life to keep symptoms down.

I know what I’m talking about because my father had a major reflux problem caused by a surgery in which a bile duct was connected to his stomach instead of his intestine. For almost a year, he suffered for GERD that was so severe he threw up several times a day.

But eventually he discovered, quite by chance, that a simple supermarket apple made him feel better. He eventually determined how much apple and what kind of apple was the best to be consumed each day to keep all of his symptoms in check for good.

There are many other things that people with acid reflux can do to eliminate their symptoms. One of the most important things is to try to stop causing irritation and scratching of your esophagus, which will just make your acid problems worse.

Eating smaller meals is often helpful for people who have acid reflux. Some people recommend not drinking during a meal, since the liquid dilutes the acid and makes it easier for the acid to reflux. On the other hand, it’s a good idea to drink a glass of water after eating, because it helps cleanse the lower esophageal sphincter, which then closes up tighter, which means less acid will be able to get to your esophagus.

Cutting back coffee, alcohol and carbonated beverages, especially at meal times, are also good natural aids to eliminating acid reflux. It’s a good idea to cut back your coffee intake to just one cup a day, because coffee is acidic. If you do continue to drink coffee, drink a glass of water right after to clear away the acid.

One of the most important things you can do if you have GERD and you smoke is to quit smoking. Of course there are all sorts of wonderful reasons to quit smoking, but one that has to do with acid reflux is that smoking actually irritates your throat. What’s more, the chemicals in cigarettes cause your lower esophageal sphincter to relax, which allows even more fluid and other unpleasantness into your esophagus. Some people find that even quitting for just a couple of days is a big help for eliminating some of their irritation.

No one remedy works for everyone, but these ideas (plus tons of others in the Reflux Remedy Report) should get you back to feeling like your old self in no time.

This article is from Biosingularity:

One of the nation’s pre-eminent genetic researchers, Eric Hoffman, PhD, of Children’s Research Institute at Children’s National Medical Center, predicts that in relatively short order, medicine’s next innovation–individualized molecular therapies–will have the unprecedented ability to treat muscular dystrophies, and other disorders.

In the latest edition of the New England Journal of Medicine, Dr. Hoffman posits that the results of a small clinical trial involving a new treatment for Duchenne muscular dystrophy provides a proof-of-principle for personalized molecular medicine. Practical implementation of the ‘exon-skipping’ approach described in the co-published report of vanDeutekom et al. will require advances in systemic administration of large amounts of customized DNA-like drugs, and proof that long-term delivery is not toxic. However, these advances are likely to come in short order, with the oversight and regulations of the FDA critical for appropriate labeling and marketing of such personalized molecular target drugs.

Though this particular treatment remains in its early stages, within the foreseeable future the now-standard Phase I, II, and III pathway to drug approvals may need to be re-evaluated.

How can DNA-like drugs specific to a single patient’s mutation go through the existing approval process” Are the current standards of rodent and monkey toxicity studies relevant and appropriate for DNA-like drugs, when the animals do not have the same DNA target (or off-target) sequences as humans” These and other questions are certain to pose exciting challenges to both the approval and marketing processes of drugs.

Read the full article here